Except that unlike the native Americans which were (mostly accidentally) severely depopulated by old world diseases, and had no access to modern mass media to gather sympathy for their cause, the Palestinians are here to stay.
The conflict with the natives in North America ended with them subjugated. That's not really an option here. The Israeli occupation is growing more and more unsustainable, mostly for economic and diplomatic reasons rather then military capability, and both sides know it.