I don't think we have a thread dedicated to them, do we?
However, web comics are quite a thing these days, here're a couple I've been following for long
Giant in the Playground's Order of the Stick; basically is a comical D&D based comic, very much Paint style. A lot of jokes on metagaming stuff, common things about Rpgs and such. It's been in development for about 17 years afaik.
Looking for Group; this one seems to be based on WoW, at the least loosely. Still much funny, but with a much better story line and drawings.
Of course both sites also offer other content, comics, etc. Enjoy