So many what ifs here! For starters, you could probably safely bet that there would be no Hanukkah celebration today.
Secondly, the Hasmonean dynasty would never be established and there would be no Herodian Kingdom by the time of the late Roman Republic and Roman Empire under Augustus. Hell, you could probably argue that the trend of Hellenized Jews would only intensify, to the point where even practices like circumcision would perhaps even die out. That's one of the practices Hellenized Jews tried to abandon in order to socialize and compete with ethnic Greeks at the gymnasium. It was also one of many Jewish practices Antiochos IV Epiphanes tried to stamp out. Historically the Jews eventually embraced the universal Koine Greek tongue and even had their own dialect for it (refer to Biblical literature on that), yet this would probably be even more pronounced in the hypothetical scenario of total Seleucid domination.
Putting culture aside and focusing on politics, the solidified control of Judea by the Seleucid Empire would have probably allowed them to earnestly invade and possibly conquer nearby Ptolemaic Egypt within a generation. Of course this would still put them on a collision course with Rome, since the Romans (with Greek allies) had already defeated and humbled the Seleucids under Antiochus III "the Great" at the Battle of Magnesia in 190 BC. It would probably drive the Ptolemies into the arms of the Romans as a protected client state earlier than in our historical record. It would perhaps embolden the Seleucids to attempt another go at invading mainland Greece and Macedonia.
The Jews mostly gave up their ideas of political independence after the Bar Kokhba Revolt against Rome in 132-136 AD. Messianism was greatly discouraged after that point and Jewish relevance on the geopolitical stage would only come about with the Zionist efforts to create the state of Israel in the 20th century. One could argue that a Seleucid victory in the Maccabean Revolt would have manufactured a similar result and the later Romans (assuming they would conquer the region in an alternative timeline) would never have to face a Jewish revolt at all. At that point the Jewish spirit for politics and independence would have long been shattered or become irrelevant due to their Hellenistic nature. Jesus would be speaking Koine Greek instead of Aramaic or whatever, and who knows what would happen to Christianity.
What do you guys think? Am I just blowing hot air or am I onto something?