Finally, there are papers out on the long-term consequences of Neanderthal admixture – one by Sriram Sankararaman in Nature, the other by Benjamin Vernot in Science.
The general picture is that anatomically modern humans exiting Africa mixed, to a degree, with Neanderthals. Some of the Neanderthal alleles were neutral, some were disadvantageous in modern humans and were lost fairly rapidly, and a few had favorable fitness consequences and have become common. All that was highly likely a priori. I would say it was obvious, if that word meant anything. It should have been the default assumption from 1927 on, after Haldane calculated the probability of success for a single copy of an advantageous allele. Wasn’t, though.
Exactly which kinds of Neanderthal alleles would give advantage was less obvious. I suspected that Neanderthals would be resistant to local pathogens, and that such genetic defenses could easily pay off in modern humans moving into Eurasia. It looks as if some of that happened – there is a good chance that some common HLA alleles in Eurasians originated in Neanderthals, and some Neanderthal variants involved with defense against viruses have become common.
I thought that anatomically modern humans might have picked up alleles that dealt better with the big swings in day length characteristic of northern latitudes. In an earlier talk, Sakararaman mentioned a common Neanderthal version of the CLOCK gene in Europeans, but that doesn’t show up in the paper, so maybe that turned out to be a mistake.
It looks as if both Europeans and East Asians have picked up Neanderthal versions of several keratin filament genes, involved in hair and skin formation. Not fixed, but pretty common. This might have something to do with the non-kinky hair found in most Eurasians.
Some of these common Neanderthal alleles may have some effect on the central nervous system, but as usual, we have such a poor understanding of gene function that it’s hard to tell. A Neanderthal variant of TANC1 is common in Europeans, and that gene is thought to regulate dendritic spines and excitatory synapses. Looking at the broader question, an unusual number of selected Neanderthal alleles were found that are associated with major depression. So maybe those alleles affected mood regulation. Perhaps depression is part of a strategy for dealing with long winters.
There are gene deserts in which you find very few Neanderthal alleles, presumably because those alleles didn’t work well in modern humans. There is a dearth of testes-associated gene, not too surprising because they evolve particularly rapidly and are therefore more likely than average to be incompatible with a sister group that diverged some time ago. The area around FOXP2 is such a desert: Neanderthals were perhaps worse at speech, or any rate different in some way that didn’t mesh.
There are some signs of reproductive incompatibility with modern humans, but obviously not enough to prevent adaptive introgression. David Reich suggests that Neanderthals were “at the very edge of being biologically incompatible”. I doubt that, for two reasons. First, the known cases of species intersterility in primates all took longer to develop. Bonobos and chimps manage, and they’ve been separated something like 800,000 years. In addition, there is evidence that African hunter-gatherers (Bushmen and Pygmies) picked up some genetic material from an unknown archaic group, one that split off considerably earlier than Neanderthals, something like 900,000 years.
Some Neanderthal haplotypes are risk alleles for various diseases. Chris Stringer said “Studies have also already been published which show that humans outside of Africa are more vulnerable to Type 2 Diabetes, and that is because we bred with Neanderthals, while those who stayed inside Africa didn’t.” Of course that is not actually true. In the US, blacks have Type 2 diabetes rates that are about twice as high as whites. Pima Indians have incredibly high rates, but they have almost exactly the same amount of Neanderthal ancestry as Europeans. I would bet that the selective environment of the past few thousand years matters more than Neanderthal ancestry, or the lack of it. That said, Neanderthal alleles can play a role in that selective process.
In our book, we suggested that the big bang of the Upper Paleolithic, the dramatic increase in cultural complexity seen in Europe some 40,000 years ago, might have been triggered, at least in part, by an influx of adaptive Neanderthal alleles. Right now, from the evidence in these papers, I’m not seeing a strong case for that. Of course we only understand what half these genes are doing, so the fat lady hasn’t finished singing, but we may well be wrong. Of course that dramatic increase in cultural complexity did happen, and for that matter, it is still true that average IQ scores are quite low in sub-Saharan Africa and its diaspora. But IQ scores are also low in populations such as Australian Aborigines that have about the same amount of Neanderthal admixture as other people outside of Africa – so at minimum the story is more complicated.
Why are humans assumed to have moved out of africa?
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Originally Posted by cenkiss
