My current Attempt so far:
Spoiler Alert, click show to read:
With this one i started off with a plan from the get go:
The bottom third i designed as intended but down the center i create a flimsy straight road and lined it with low quality industry, once i got to roughly the high density stage i bulldozed this entire area and replaced it with a large road system that you see now. I also relocated my garbage system to the north with easy access to the entire area.
I moved the low density industry to the other side of the highway, made it into logging and recently added a train network to help redistribute produced goods.
Next step will be to start construction on an island to the south and fill in as much as my current city as possible.
Also look into building a Dam and other clean energy sources.