I'm playing as Rome on normal right now. I'm at about turn 75, and Pergamon, Pontus, Bithynia, and the Seleucids have formed an alliance. Together, they control a large region, but no single faction has really run rampant. You can see in these attached images, though, that Pergamon only has two settlements. The most expansive have been the Suebi and Seleucids. Both have had back and forth territorial changes though. The Scythians recently formed a horde and have been pretty aggressive, but they're having trouble with the Suebi.
Overall, I've been fairly impressed with the balance. It's fun having a campaign where no individual faction just rolls over everyone (excluding me, of course
). It's been a nice, casual campaign so far. The biggest challenge I've faced has been an attack from the Illyrians when they confederated. They're now my client state.