It will be drastically overwhelming to play everything, seeing as how it is already very difficult to fill up a game with maximum amount of players...
A small region, where we're all fairly close would make more sense for any RPG. You could be in Cuba, I could be in Quebec, Lucius could be in Virginia, Gandalf in Brazil.. (sic)
That's FAR too broad to play with a handful of players. It makes more sense that we're all one or the other (ideally not Spanish considering the size of their land), but instead Brits, in the same general area, with the same general cause.
Just makes more sense that way to me. Keep in mind we're in 1650, there's going to be no visiting Florida from Brazil without a 3 month journey for example
Edit: That all being said, I would be more for 1754-63, 1775-1783, or 1861-1865 eras to be honest (if you understand these numbers, then you can guess what I'm insinuating)