I've just looked at Wikipedia and read that Thessalonica's population in 1478 was only ~10,000. However, if we look to the past, the Muslims enslaved 22,000 young people in the Sack of Thessalonica, 904, according to Wikipedia. During the Komnenian Restoration the city thrived and, with prosper peace, the population increased. I could easily imagine Thessalonica's population to be at least 100,000-200,000 by ~1150, after all, she was the Symbasileiousa, co-empress. I think she should be included in the huge city's list and should start out at least as a large city. Maybe Trebizond, Alexandria, Isfahan, Damascus and Nicaea could be included into the huge city list?