With TSE campaign you need to be very careful about recruiting early on. Spend most of your money upgrading the economic infrastructure - roads, markets, law temples. Militarily your first move should be to capture Side and Salamis, then push the Ptolemies out of the Levant. After that you should work on slowly gaining ground in Asia Minor. It is very hard to defend the far east of the empire, so you should probably just try to slow the advance of Parthia and Baktria. If you can buy some Indian Elephants that helps a lot.
With Macedon, all you need to do is break the Galatian threat and then conquer Greece.
