I wonder if anyone else noticed this. I'm currently playing a peaceful game as Great Britain and have trade agreements with every major european power and some minor nations.
However, by 1950 my trade window only shows 6 trade agreements, although I'm currently having at least 10. This probably happens because some nations like United Provinces and Austria got defeated and reemerged, I'm still having the trade agreements in place with them but we're not trading anymore. The same happens when a nation looses the province with its trading port (usually their main province) like Sweden or Spain, even if they eventually recapture it or get it back by rebellion, the trade agreements don't work anymore.
The only way to get them working again is by cancelling the agreement and negotiating a new one. But unfortunately, most nations don't want that anymore because I'm too powerful by now... 
Funny thing: Russia is even listed twice because they captured the main region of the Ottoman empire and are now using their trade port as well. 
screenshot of my trade window: