Hi. First of all, I would like to say thank you for this mod. It's amazing work, and learning of it prompted me to reinstall Empire.
I played this mod for the first time last night, and got about 17 turns in with Spain, before saving a final time and shutting down. Upon trying to load my save, the game crashed. It also crashed on three previous saves that I tried. I then tried to start a new campaign, which also caused a crash.
In short: the game loads up fine, but when I attempt to load a game or start a new one, the game crashes.