No, don't actually forget the Yanks, just leave them aside for the moment. Everyone here seems to concentrate on how the US emerges and how the US Revolution (Rebellion?) will happen in the game. But another revolution took place in the same period (+10 years) which had a much greater impace in the short term - the French Revolution. It led to nearly 30 years of continuous warfare and untold bloodshed and very much shaped the world right up to WW2.
Does it happen in the game? How will it happen? Does France have to go through a period of Terror? How do you deal with other continental powers whilst it is happening? Do you basically have to expand aggresively to keep the masses occupied?